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In 1989, a breakthrough in advanced parasitic research on Cuttyhunk Island, gave scientists a jump in human evolution. Initial tests proved promising as subjects were experiencing heightened physical and mental strength and awareness. But, something in the experiment went horribly wrong and the island mysteriously lost three quarters of its population. Jamie Akerman fled the outbreak, which took her mothers life, twenty years ago. She now returns with her boyfriend and step brother, to sell the family property. There, they uncover the key to Jamie's disturbing past, and the horrifying secrets long suppressed by the town leader, Larkin. Now, a new strain of parasite has emerged, and threatens the island once again. Jamie struggles to survive and escape the obsessive pursuit of the local islanders who know that she has inherited more than she could ever have imagined.

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Jessica moves into a loft on the eighth floor of a Los Angeles apartment building called The Dante. The other tenants all seem friendly at first, but when she starts witnessing horrible deaths, she must team up with her neighbor Evan (Doom) to solve the mystery -- and uncover her own connection to the place.